Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis

Oncogene. 2005 Sep 5;24(39):5931-7. doi: 10.1038/sj.onc.1208981.


I briefly review the discovery and characterization of the first human retrovirus, human T-cell leukemia virus type 1, focusing on contributions from Japanese researchers. The unique regulatory mechanisms for the viral regulation with Tax and Rex, etiology of ATL and possible leukemogenic mechanism with Tax are also discussed briefly.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Genes, pX
  • HTLV-I Infections / history
  • History, 20th Century
  • Human T-lymphotropic virus 1 / classification*
  • Human T-lymphotropic virus 1 / genetics
  • Human T-lymphotropic virus 1 / isolation & purification*
  • Human T-lymphotropic virus 1 / pathogenicity
  • Humans
  • Japan