Liquid bandage (2-octyl cyanoacrylate) as a temporary wound barrier in clear corneal cataract surgery

Ophthalmology. 2005 Nov;112(11):2015-21. doi: 10.1016/j.ophtha.2005.05.014. Epub 2005 Sep 12.


Purpose: To determine the feasibility and side effect profile of 2-octyl cyanoacrylate with parabens (Liquid Bandage) as an adjunct wound sealant and barrier against the inflow of ocular surface fluid after clear corneal cataract surgery.

Design: Prospective interventional case series.

Participants: Fifty-one eyes of 51 patients undergoing clear corneal cataract surgery.

Methods: Fifty-one eyes of 51 patients who underwent cataract surgery by one surgeon (RSK) were enrolled. A 2.75-mm clear corneal, triplanar, temporal incision was used in each case, followed by routine phacoemulsification. At the conclusion of each case, the wound was dried with a cellulose sponge. A modified microsponge with 1 to 2 drops of 2-octyl cyanoacrylate with parabens was then applied in a smooth layer to the wound. All wounds were rechecked for leakage with a cellulose sponge applied at the wound lip. The following criteria were evaluated on the first 2 postoperative visits: (1) visual acuity; (2) patient complaints; (3) wound integrity; (4) presence of tissue adhesive; and (5) any adverse events, including abnormal increase in local tissue reaction to the adhesive.

Main outcome measures: Side effect profile and clinical course of 2-octyl cyanoacrylate with parabens applied to clear corneal wounds.

Results: All 51 eyes demonstrated intraoperative watertight wound closure after the application of 2-octyl cyanoacrylate with parabens. Forty-five eyes (88%) had tissue adhesive still completely covering the wound on postoperative day 1. Two eyes (4%) had tissue adhesive over portions of their wound, and 4 eyes (8%) had no adhesive noted on their wound. All wounds were watertight on all postoperative visits. Thirty-one of 51 patients (61%) complained of mild transient foreign body sensation on postoperative day 1. Twenty-six patients (51%) had trace diffuse bulbar conjunctival hyperemia. Five patients had trace focal conjunctival hyperemia adjacent to the wound. Nine patients (18%) had remnants of the adhesive remaining on the second postoperative visit.

Conclusions: Our study demonstrates the ease of use and applicability and low side effect profile of 2-octyl cyanoacrylate with parabens as a temporary wound barrier in clear corneal cataract surgery.

MeSH terms

  • Cornea / drug effects*
  • Cornea / surgery
  • Cyanoacrylates / therapeutic use*
  • Endophthalmitis / prevention & control
  • Humans
  • Parabens / therapeutic use
  • Phacoemulsification / methods*
  • Pilot Projects
  • Prospective Studies
  • Surgical Wound Infection / prevention & control
  • Tissue Adhesives / therapeutic use*
  • Wound Healing / drug effects*


  • Cyanoacrylates
  • Parabens
  • Tissue Adhesives
  • octyl 2-cyanoacrylate