Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways

Vascul Pharmacol. 2005 Oct;43(4):234-41. doi: 10.1016/j.vph.2005.07.003. Epub 2005 Sep 12.


Ginger is a world known food plant which is equally reputed for its medicinal properties. We report here the hypotensive, endothelium-dependent and independent vasodilator and cardio-suppressant and stimulant effects of its aqueous extract (Zo.Cr). Zo.Cr, which tested positive for saponins, flavonoids, amines, alkaloids and terpenoids, induced a dose-dependent (3.0-10.0 mg/kg) fall in the arterial blood pressure (BP) of anaesthetized rats which was partially blocked by atropine (1 mg/kg). In isolated endothelium-intact rat aorta, Zo.Cr (0.01-5.0 mg/ml) relaxed the phenylephrine (1 microM)-induced contractions, effect partially blocked by atropine (1 microM). Zo.Cr inhibited the K+ (80 mM)-induced contractions and also shifted the Ca++ dose-response curves to the right, similar to verapamil, indicating Ca++ antagonist activity. An atropine-resistant and l-NAME-sensitive vasodilator activity was also noted from ginger phenolic constituents 6-, 8- and 10-gingerol, while 6-shogaol showed a mild vasodilator effect. In guinea-pig atria, Zo.Cr (0.1-5.0 mg/ml) inhibited the force and rate of atrial contractions. Pretreatment with atropine blocked the inhibitory effect and a stimulatory effect was unmasked which was resistant to propranolol and verapamil but sensitive to ryanodine, blocker of Ca++ release from intracellular stores. Later at doses >or=1.0 mg/ml, the extract completely suppressed the atrial tissue, effect resistant to glibenclamide, pyrilamine, aminophylline and L-NAME. These data indicate that the aqueous ginger extract lowers BP through a dual inhibitory effect mediated via stimulation of muscarinic receptors and blockade of Ca++ channels and this study provides sound mechanistic basis for the use of ginger in hypertension and palpitations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthesia
  • Animals
  • Aorta, Thoracic / drug effects
  • Blood Pressure / drug effects
  • Calcium / antagonists & inhibitors
  • Cardiovascular Agents*
  • Catechols / pharmacology
  • Chromatography, Thin Layer
  • Dose-Response Relationship, Drug
  • Fatty Alcohols / pharmacology
  • Female
  • Ginger / chemistry*
  • Guinea Pigs
  • In Vitro Techniques
  • Male
  • Nitric Oxide / metabolism
  • Phenols / pharmacology*
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Rats


  • Cardiovascular Agents
  • Catechols
  • Fatty Alcohols
  • Phenols
  • Plant Extracts
  • Nitric Oxide
  • shogaol
  • gingerol
  • Calcium