Hypoxia-inducible factor as a physiological regulator

Exp Physiol. 2005 Nov;90(6):791-7. doi: 10.1113/expphysiol.2005.030924. Epub 2005 Sep 12.


Hypoxia-inducible factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with a master regulator that coordinates changes in gene transcription. HIF operates in all mammalian cell types and is ancient in evolutionary terms, being conserved in C. elegans and D. melanogaster. This review summarizes recent insights into the molecular events that link reduced oxygenation to HIF activation and emerging insights into the extensive role of HIF in a broad range of physiological processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Hypoxia-Inducible Factor 1 / drug effects
  • Hypoxia-Inducible Factor 1 / genetics
  • Hypoxia-Inducible Factor 1 / physiology*
  • Hypoxia-Inducible Factor-Proline Dioxygenases
  • Immediate-Early Proteins / metabolism
  • Oxygen / pharmacology
  • Procollagen-Proline Dioxygenase / metabolism


  • Hypoxia-Inducible Factor 1
  • Immediate-Early Proteins
  • EGLN1 protein, human
  • Procollagen-Proline Dioxygenase
  • Hypoxia-Inducible Factor-Proline Dioxygenases
  • Oxygen