Genotoxicity study in lymphocytes of offset printing workers

J Appl Toxicol. 2006 Jan-Feb;26(1):10-5. doi: 10.1002/jat.1098.


The potential cytogenetic damage in offset printing workers was evaluated using sister chromatid exchanges (SCEs), chromosome aberrations (CAs) and micronuclei (MN) as biomarkers in peripheral lymphocytes of 26 volunteers (14 workers, 12 controls). The CA, SCE and MN frequency of offset printing workers was significantly higher than in their controls. The replication index (RI) was not affected while the mitotic index (MI) was affected most in the workers. It can be concluded from this study that chronic occupational exposure to printing dyes and thinner may lead to a slightly increased risk of genetic damage among offset printing workers.

MeSH terms

  • Adolescent
  • Adult
  • Cell Proliferation / drug effects
  • Chromosome Aberrations / chemically induced*
  • Coloring Agents / toxicity
  • Humans
  • Lymphocytes
  • Male
  • Micronuclei, Chromosome-Defective / chemically induced*
  • Middle Aged
  • Mitotic Index
  • Occupational Exposure*
  • Printing*
  • Sister Chromatid Exchange*
  • Smoking
  • Solvents / toxicity
  • Toluene / toxicity


  • Coloring Agents
  • Solvents
  • Toluene