doi: 10.1021/jf0514064.
Identification of benzalkonium chloride in commercial grapefruit seed extracts
Affiliations
- PMID: 16159196
- DOI: 10.1021/jf0514064
Item in Clipboard
Identification of benzalkonium chloride in commercial grapefruit seed extracts
J Agric Food Chem.
.
Abstract
Commercial grapefruit seed extracts (GSE) were extracted with chloroform. The solvent was evaporated, and the resulting solid was subsequently analyzed by high-performance liquid chromatography (HPLC), electrospray ionization mass spectrometry (ESI/MS), tandem mass spectrometry (ESI/MS/MS), and elemental analysis (by proton-induced X-ray emission analysis). Three major constituents were observed by HPLC and were identified as benzyldimethyldodecylammonium chloride, benzyldimethyltetradecylammonium chloride, and benzyldimethylhexadecylammonium chloride. This mixture of homologues is commonly known as benzalkonium chloride, a widely used synthetic antimicrobial ingredient used in cleaning and disinfection agents.
Similar articles
-
Identification of benzethonium chloride in commercial grapefruit seed extracts.J Agric Food Chem. 2001 Jul;49(7):3316-20. doi: 10.1021/jf010222w. J Agric Food Chem. 2001. PMID: 11453769
-
Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract.Pharmazie. 2007 Aug;62(8):593-6. Pharmazie. 2007. PMID: 17867553
-
Development and validation of an HPLC/UV/MS method for simultaneous determination of 18 preservatives in grapefruit seed extract.J Agric Food Chem. 2006 May 31;54(11):3768-72. doi: 10.1021/jf060543d. J Agric Food Chem. 2006. PMID: 16719494
-
[Survey of synthetic disinfectants in grapefruit seed extract and its compounded products].Shokuhin Eiseigaku Zasshi. 2008 Feb;49(1):56-62. doi: 10.3358/shokueishi.49.56. Shokuhin Eiseigaku Zasshi. 2008. PMID: 18344660 Japanese.
-
Grapefruit and its biomedical, antigenotoxic and chemopreventive properties.Food Chem Toxicol. 2018 Feb;112:224-234. doi: 10.1016/j.fct.2017.12.038. Epub 2017 Dec 25. Food Chem Toxicol. 2018. PMID: 29284137 Review.
Cited by 9 articles
-
Polyphenol-Rich Larix decidua Bark Extract with Antimicrobial Activity against Respiratory-Tract Pathogens: A Novel Bioactive Ingredient with Potential Pharmaceutical and Nutraceutical Applications.Antibiotics (Basel). 2021 Jun 28;10(7):789. doi: 10.3390/antibiotics10070789. Antibiotics (Basel). 2021. PMID: 34203520 Free PMC article.
-
Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450.Chem Res Toxicol. 2019 Dec 16;32(12):2466-2478. doi: 10.1021/acs.chemrestox.9b00293. Epub 2019 Dec 3. Chem Res Toxicol. 2019. PMID: 31730751 Free PMC article.
-
Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain.Toxicol Sci. 2019 Jun 14;171(1):32-45. doi: 10.1093/toxsci/kfz139. Online ahead of print. Toxicol Sci. 2019. PMID: 31199489 Free PMC article.
-
Inhibitory effect of grapefruit seed extract (GSE) on avian pathogens.J Vet Med Sci. 2019 Mar 30;81(3):466-472. doi: 10.1292/jvms.18-0754. Epub 2019 Feb 4. J Vet Med Sci. 2019. PMID: 30713281 Free PMC article.
-
Air and Surface Sampling Method for Assessing Exposures to Quaternary Ammonium Compounds Using Liquid Chromatography Tandem Mass Spectrometry.Ann Work Expo Health. 2017 Jul 1;61(6):724-736. doi: 10.1093/annweh/wxx037. Ann Work Expo Health. 2017. PMID: 28927165 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
