Bilateral panuveitis in HIV-1-infected patients with CD8 lymphocytosis

Ocul Immunol Inflamm. Jul-Aug 2005;13(4):311-6. doi: 10.1080/09273940590950954.

Abstract

Aims: To report the presence of HIV-1-infected patients with bilateral panuveitis, CD8 lymphocytosis, and an absence of parotid involvement.

Methods: Case series of four HIV-1-infected patients naive to antiretroviral treatment.

Results: Four patients with symptomatic panuveitis are presented. Ocular, systemic, and investigation findings are reported. Recognised causes of panuveitis were excluded. All patients showed a clinical response to steroids and antiretroviral therapy.

Conclusions: Symptomatic panuveitis may occur in HIV-1-infected individuals with CD8 lymphocytosis in the absence of a recognised cause. These patients have clinical features that resemble diffuse infiltrative lymphocytosis syndrome and may represent a subgroup of this syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active
  • Antiviral Agents / therapeutic use
  • CD4-CD8 Ratio
  • CD8-Positive T-Lymphocytes / immunology*
  • Dexamethasone / therapeutic use
  • Female
  • Functional Laterality
  • Glucocorticoids / therapeutic use
  • HIV Infections / complications*
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy
  • HIV-1
  • Humans
  • Lymphocytosis / complications*
  • Lymphocytosis / diagnosis
  • Lymphocytosis / drug therapy
  • Male
  • Panuveitis / complications*
  • Panuveitis / diagnosis
  • Panuveitis / drug therapy
  • Prednisolone / therapeutic use

Substances

  • Antiviral Agents
  • Glucocorticoids
  • Dexamethasone
  • Prednisolone