Alopecia areata treatment with a phototoxic dose of UVA and topical 8-methoxypsoralen

J Eur Acad Dermatol Venereol. 2005 Sep;19(5):552-5. doi: 10.1111/j.1468-3083.2005.01226.x.


Twenty-five patients with alopecia totalis (AT) or alopecia universalis and 124 patients with alopecia areata (AA) were treated with photochemotherapy, combining topical 8-methoxypsoralen (8-MOP) with UV irradiation of the scalp at a phototoxic dose. The mean energy required was 15 J/cm2 for AA and 42 J/cm2 for AT. Ninety-four patients had multiple bald patches and 12 with AT had complete or > 50% hair regrowth. Positive treatment results did not seem to depend on the age of onset or the duration of the disease. Few side-effects of topical psoralens plus UVA (PUVA) treatment were noted, except a for few days of slight erythema caused by the high dose of UV.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Alopecia Areata / diagnosis*
  • Alopecia Areata / drug therapy*
  • Child
  • Esthetics
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Methoxsalen / therapeutic use*
  • Middle Aged
  • PUVA Therapy / methods*
  • Patient Satisfaction
  • Photochemotherapy / methods
  • Prospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome


  • Methoxsalen