Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Oct;35(10):1399-409.
doi: 10.1017/S0033291705005167.

Brain MRI Abnormalities in Schizophrenia: Same Genes or Same Environment?

Affiliations

Brain MRI Abnormalities in Schizophrenia: Same Genes or Same Environment?

F V Rijsdijk et al. Psychol Med. .

Abstract

Background: Structural brain volume abnormalities are among the most extensively studied endophenotypes in schizophrenia. Bivariate genetic model fitting (adjusted to account for selection) was used to quantify the genetic relationship between schizophrenia and brain volumes and to estimate the heritability of these volumes.

Method: We demonstrated by simulation that the adjusted genetic model produced unbiased estimates for endophenotype heritability and the genetic and environmental correlations. The model was applied to brain volumes (whole brain, hippocampus, third and lateral ventricles) in a sample of 14 monozygotic (MZ) twin pairs concordant for schizophrenia, 10 MZ discordant pairs, 17 MZ control pairs, 22 discordant sibling pairs, three concordant sibling pairs, and 114 healthy control subjects.

Results: Whole brain showed a substantial heritability (88%) and lateral ventricles substantial common environmental effects (67%). Whole brain showed a significant genetic correlation with schizophrenia, whereas lateral ventricles showed a significant individual specific correlation with schizophrenia. There were significant familial effects for hippocampus and third ventricle, but the analyses could not resolve whether these were genetic or environmental in origin (around 30%each).

Conclusions: Using genetic model fitting on twin and sibling data we have demonstrated differential sources of covariation between schizophrenia and brain volumes, genetic in the case of whole brain volume and individual specific environment in the case of lateral ventricles.

Similar articles

See all similar articles

Cited by 31 articles

  • No evidence of associations between ADHD and event-related brain potentials from a continuous performance task in a population-based sample of adolescent twins.
    Lau-Zhu A, Tye C, Rijsdijk F, McLoughlin G. Lau-Zhu A, et al. PLoS One. 2019 Oct 4;14(10):e0223460. doi: 10.1371/journal.pone.0223460. eCollection 2019. PLoS One. 2019. PMID: 31584981 Free PMC article.
  • The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder.
    de Zwarte SMC, Brouwer RM, Agartz I, Alda M, Aleman A, Alpert KI, Bearden CE, Bertolino A, Bois C, Bonvino A, Bramon E, Buimer EEL, Cahn W, Cannon DM, Cannon TD, Caseras X, Castro-Fornieles J, Chen Q, Chung Y, De la Serna E, Di Giorgio A, Doucet GE, Eker MC, Erk S, Fears SC, Foley SF, Frangou S, Frankland A, Fullerton JM, Glahn DC, Goghari VM, Goldman AL, Gonul AS, Gruber O, de Haan L, Hajek T, Hawkins EL, Heinz A, Hillegers MHJ, Hulshoff Pol HE, Hultman CM, Ingvar M, Johansson V, Jönsson EG, Kane F, Kempton MJ, Koenis MMG, Kopecek M, Krabbendam L, Krämer B, Lawrie SM, Lenroot RK, Marcelis M, Marsman JC, Mattay VS, McDonald C, Meyer-Lindenberg A, Michielse S, Mitchell PB, Moreno D, Murray RM, Mwangi B, Najt P, Neilson E, Newport J, van Os J, Overs B, Ozerdem A, Picchioni MM, Richter A, Roberts G, Aydogan AS, Schofield PR, Simsek F, Soares JC, Sugranyes G, Toulopoulou T, Tronchin G, Walter H, Wang L, Weinberger DR, Whalley HC, Yalin N, Andreassen OA, Ching CRK, van Erp TGM, Turner JA, Jahanshad N, Thompson PM, Kahn RS, van Haren NEM. de Zwarte SMC, et al. Biol Psychiatry. 2019 Oct 1;86(7):545-556. doi: 10.1016/j.biopsych.2019.03.985. Epub 2019 Jun 13. Biol Psychiatry. 2019. PMID: 31443932 Free PMC article.
  • Polygenic risk score increases schizophrenia liability through cognition-relevant pathways.
    Toulopoulou T, Zhang X, Cherny S, Dickinson D, Berman KF, Straub RE, Sham P, Weinberger DR. Toulopoulou T, et al. Brain. 2019 Feb 1;142(2):471-485. doi: 10.1093/brain/awy279. Brain. 2019. PMID: 30535067 Free PMC article.
  • Neuroimaging genomics in psychiatry-a translational approach.
    Mufford MS, Stein DJ, Dalvie S, Groenewold NA, Thompson PM, Jahanshad N. Mufford MS, et al. Genome Med. 2017 Nov 27;9(1):102. doi: 10.1186/s13073-017-0496-z. Genome Med. 2017. PMID: 29179742 Free PMC article. Review.
  • A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.
    Ranlund S, Calafato S, Thygesen JH, Lin K, Cahn W, Crespo-Facorro B, de Zwarte SMC, Díez Á, Di Forti M; GROUP, Iyegbe C, Jablensky A, Jones R, Hall MH, Kahn R, Kalaydjieva L, Kravariti E, McDonald C, McIntosh AM, McQuillin A; PEIC, Picchioni M, Prata DP, Rujescu D, Schulze K, Shaikh M, Toulopoulou T, van Haren N, van Os J, Vassos E, Walshe M; WTCCC2, Lewis C, Murray RM, Powell J, Bramon E. Ranlund S, et al. Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):21-34. doi: 10.1002/ajmg.b.32581. Epub 2017 Aug 29. Am J Med Genet B Neuropsychiatr Genet. 2018. PMID: 28851104 Free PMC article.
See all "Cited by" articles

Publication types

Feedback