Brain metastasis of alveolar echinococcosis in a hyperendemic focus of Echinococcus multilocularis infection

Trans R Soc Trop Med Hyg. 2005 Dec;99(12):937-41. doi: 10.1016/j.trstmh.2005.04.020. Epub 2005 Sep 13.

Abstract

An unusual female case, with alveolar echinococcosis (AE) disseminated from the primary hepatic lesion to the brain by metastasis formation, was retrospectively identified during a community survey in Ningxia Hui Autonomous Region, northwest China in 2003. Among possible metastases of hepatic AE, locations to the brain are rare and usually fatal; and they have especially been assigned to concomitant immune suppression. An enhancing role of pregnancy, which may be suspected in this case, the favourable outcome after surgery and chemotherapy, and also a mental disability in a child following long-term intrauterine exposure to mebendazole, make the report particularly unique.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Abnormalities, Drug-Induced / etiology
  • Anthelmintics / adverse effects
  • Brain Diseases / parasitology
  • Brain Diseases / pathology*
  • Central Nervous System Protozoal Infections / parasitology
  • Central Nervous System Protozoal Infections / pathology*
  • Echinococcosis / drug therapy
  • Echinococcosis / pathology*
  • Echinococcosis, Hepatic / drug therapy
  • Echinococcosis, Hepatic / pathology
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Maternal-Fetal Exchange
  • Mebendazole / adverse effects
  • Pregnancy
  • Pregnancy Complications, Parasitic / drug therapy

Substances

  • Anthelmintics
  • Mebendazole