Intracranial involvement in Hodgkin's disease

Pediatr Hematol Oncol. Oct-Nov 2005;22(7):589-96. doi: 10.1080/08880010500198863.

Abstract

The authors report 3 cases of Hodgkin's disease with intracranial involvement. The patients were 4, 12, and 15 years old (male/female=1/2). Initially, they were treated with ABVD or COPP chemotherapies and low-dose involved field radiotherapy. Intracranial recurrences occurred 27, 40, and 42 months after initial diagnosis, respectively. Two patients experienced convulsions and the other complained of diplopia. The metastatic lesions were located supratentorially with CT or MRI. Despite initial response achieved following systemic chemotherapy and external irradiation to cranial lesions, all patients died with disseminated disease. In patients with intracranial involvement of Hodgkin's disease, prolonged disease-free survival may be achieved by combined modality treatment.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Bleomycin / administration & dosage
  • Brain Neoplasms* / diagnostic imaging
  • Brain Neoplasms* / etiology
  • Brain Neoplasms* / therapy
  • Child
  • Child, Preschool
  • Combined Modality Therapy / methods
  • Cranial Irradiation / methods
  • Cyclophosphamide / administration & dosage
  • Dacarbazine / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Hodgkin Disease / complications*
  • Hodgkin Disease / drug therapy
  • Humans
  • Male
  • Neoplasms, Second Primary* / diagnostic imaging
  • Neoplasms, Second Primary* / etiology
  • Neoplasms, Second Primary* / therapy
  • Prednisone / administration & dosage
  • Procarbazine / administration & dosage
  • Radiography
  • Recurrence
  • Vinblastine / administration & dosage
  • Vincristine / administration & dosage

Substances

  • Bleomycin
  • Procarbazine
  • Vincristine
  • Vinblastine
  • Dacarbazine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • ABVD protocol
  • COPP protocol