Immune Recovery Uveitis and Human Leukocyte Antigen Typing: A Report on Four Patients

Eur J Ophthalmol. Sep-Oct 2005;15(5):607-9. doi: 10.1177/112067210501500511.

Abstract

Purpose: To report the typing of human leukocyte antigen (HLA) in four human immunodeficiency virus-positive (HIV) patients with immune recovery uveitis (IRU).

Methods: The medical history of four consecutive patients who presented at the Ocular Immunology and Uveitis Service (University Hospital San Raffaele, Milan, Italy) with definite diagnosis of IRU is reported. The HLA typing was tested in all patients.

Results: All patients presented the clinical and ophthalmological characteristics of IRU. The HLA typing analysis showed the presence of HLA B 8-18 in all patients.

Conclusions: The data obtained from these patients indicate the presence of the same HLA typing (B 8-18). The clinical relevance of such association needs to be further evaluated.

MeSH terms

  • Adult
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / immunology*
  • Cytomegalovirus Retinitis / immunology
  • Female
  • HIV Infections / drug therapy
  • HIV Infections / immunology*
  • HLA-B Antigens / analysis*
  • Histocompatibility Testing
  • Humans
  • Male
  • Uveitis / immunology*

Substances

  • Anti-HIV Agents
  • HLA-B Antigens