We investigated the epidemiology of Musculoskeletal Symptoms (MSS) among Korean nursing students using a validated, questionnaire survey. Among 202 students, the prevalence of MSS at any body site ranged from 69.0% to 77.1% (overall rate: 73.3%). MSS was most commonly reported at the shoulder (46.0%), followed by the lower back (39.1%), neck (35.6%), feet (25.2%) and lower legs (23.8%). Logistic regression analysis indicated that students who undertook regular exercise were only half as likely to report an MSS at any body site (OR 0.5, 95% CI 0.2 - 0.9, P = 0.0350). Increasing body weight was also correlated with a decreased likelihood of MSS (OR 0.04, 95% CI 0.002 - 0.9, P = 0.0460). Overall, our study has shown that Korean nursing students report a high prevalence of MSS, when compared to their international counterparts. Their MSS burden is roughly comparable with Korean workers, in a variety of occupations. Further investigations will now be required to elucidate the contributory factors for nursing students' MSS in Korea, as elsewhere.