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. 2005 Nov 4;336(4):1144-9.
doi: 10.1016/j.bbrc.2005.08.243.

Induction of Tamoxifen Resistance in Breast Cancer Cells by ELF Electromagnetic Fields

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Induction of Tamoxifen Resistance in Breast Cancer Cells by ELF Electromagnetic Fields

Rainer Girgert et al. Biochem Biophys Res Commun. .

Abstract

The incidence of breast cancer in western societies has been rising ever since the Second World War. Besides the exposure to a multitude of new chemical compounds, electromagnetic field exposure has been linked to breast cancer through a radiation-mediated anti-melatonin pathway. We investigated, whether low-frequency electromagnetic field exposure interferes with the anti-estrogenic activity of tamoxifen. Two different clones of the breast cancer cell line MCF-7 were exposed to highly homogeneous 50Hz electromagnetic fields and IC(50) values were calculated from dose-response curves of tamoxifen at various field intensities. An intensity-dependent shift of tamoxifen dose-response curves to higher concentrations with a maximal response at 1.2muT was observed. Hypothetically, electromagnetic field exposure could contribute to tamoxifen resistance observed in breast cancer after long-term treatment.

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