Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: synthesis, characterization, and DNA cleavage

Wei Peng; Pei-Yan Liu; Ning Jiang; Hong-Hui Lin; Guo-Lin Zhang; Yi Liu; Xiao-Qi Yu

doi:10.1016/j.bioorg.2005.07.003

Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: synthesis, characterization, and DNA cleavage

Bioorg Chem. 2005 Oct;33(5):374-85. doi: 10.1016/j.bioorg.2005.07.003.

Authors

Wei Peng¹, Pei-Yan Liu, Ning Jiang, Hong-Hui Lin, Guo-Lin Zhang, Yi Liu, Xiao-Qi Yu

Affiliation

¹ Department of Chemistry, Key Laboratory of Green Chemistry and Technology ,Ministry of Education, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China.

PMID: 16168459
DOI: 10.1016/j.bioorg.2005.07.003

Abstract

Dinuclear macrocyclic polyamine zinc(II) complexes, which have two cyclen groups linked by flexible spacers, have been synthesized as DNA cleavage agents. The structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, MS and 1H NMR spectroscopy. The catalytic activity of these dinuclear complexes on DNA cleavage was studied. The results showed that the dinuclear zinc(II) complexes can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) (Form I) under physiological conditions to produce selectively nicked DNA (Form II).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry*
Hydrolysis
Indicators and Reagents
Macrocyclic Compounds / chemical synthesis*
Models, Molecular
Plasmids / chemistry
Polyamines / chemical synthesis*
Zinc*

Substances

Indicators and Reagents
Macrocyclic Compounds
Polyamines
DNA
Zinc