Sarcoidosis mimicking recurrent endometrial cancer

Gynecol Oncol. 2005 Dec;99(3):770-3. doi: 10.1016/j.ygyno.2005.08.002. Epub 2005 Sep 15.


Background: Sarcoidosis is a multisystem disease and can be confused with benign or malignant tumors. In patients with recurrent gynecologic cancer, liver and intrathoracic lesions should undergo a biopsy to rule in metastatic malignancy, as clinical findings and CAT scan results may represent other disease processes.

Case: A 67 year old woman had a total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic and periaortic lymphadenectomy, and peritoneal cytology in 2001 for Stage I B grade 1 adenocarcinoma of the endometrium. She developed a vaginal recurrence in 2005. A CT scan of lungs, abdomen, and pelvis revealed extensive mediastinal adenopathy and multiple space occupying hepatic lesions worrisome for metastatic disease. A needle biopsy of the largest liver lesion revealed sarcoidosis.

Conclusion: Sarcoid lesions may mimic metastatic disease in patients with malignancy, potentially leading to delayed and/or inappropriate therapy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Endometrial Neoplasms / diagnosis*
  • Endometrial Neoplasms / pathology
  • Female
  • Humans
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / pathology
  • Sarcoidosis / diagnosis*
  • Sarcoidosis / pathology