Successful treatment of Paecilomyces variotii splenic abscesses: a rare complication in a previously unrecognized chronic granulomatous disease child

Shih-Min Wang; Chi-Chang Shieh; Ching-Chuan Liu

doi:10.1016/j.diagmicrobio.2005.04.015

Successful treatment of Paecilomyces variotii splenic abscesses: a rare complication in a previously unrecognized chronic granulomatous disease child

Diagn Microbiol Infect Dis. 2005 Oct;53(2):149-52. doi: 10.1016/j.diagmicrobio.2005.04.015. Epub 2005 Sep 15.

Authors

Shih-Min Wang¹, Chi-Chang Shieh, Ching-Chuan Liu

Affiliation

¹ Department of Emergency Medicine, National Cheng Kung University and Hospital, Tainan 70428, Taiwan.

PMID: 16168619
DOI: 10.1016/j.diagmicrobio.2005.04.015

Abstract

A case of splenic abscesses caused by Paecilomyces variotii in a 21-month-old child with previously undiagnosed chronic granulomatous disease (CGD) is described. An X-linked form of CGD with deficiency of gp91-phox was diagnosed. The fungal pathogen was isolated from the abscess contents. Cure was achieved by a partial splenectomy and a prolonged fluconazole and flucytosine combination treatment regimen. P. variotii is an emerging fungus in children with CGD. Every effort should be made to recover the possible underlying immunodeficiency in children with paecilomycosis.

Publication types

Case Reports

MeSH terms

Abscess / etiology
Abscess / microbiology*
Granulomatous Disease, Chronic / complications*
Humans
Infant
Male
Mycoses / complications
Mycoses / drug therapy
Mycoses / microbiology*
Paecilomyces*
Spleen / microbiology*