Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques

Neurosci Lett. 2005 Dec 23;390(2):87-92. doi: 10.1016/j.neulet.2005.08.028.

Abstract

APP(695)SWE/co+PS1/DeltaE9 mice with Abeta plaques in neocortex and hippocampus were evaluated in tests of exploratory activity and spatial learning. On the initial testing day, 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP(695)SWE/co+PS1/DeltaE9 mice were impaired during acquisition of the hidden platform sub-task and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amyloid beta-Protein Precursor* / genetics
  • Amyloid beta-Protein Precursor* / metabolism
  • Animals
  • Behavior, Animal / physiology
  • Brain / anatomy & histology
  • Brain / pathology
  • Exploratory Behavior / physiology*
  • Humans
  • Male
  • Maze Learning / physiology*
  • Mice
  • Mice, Transgenic*
  • Plaque, Amyloid / metabolism*
  • Plaque, Amyloid / pathology

Substances

  • Amyloid beta-Protein Precursor