Twin gestation induced by clomiphene citrate and bromocriptine in both horns of a bicornuate uterus

Fertil Steril. 2005 Sep;84(3):756. doi: 10.1016/j.fertnstert.2005.02.048.


Objective: To describe a case of twin gestation that occurred in both horns of a bicornuate uterus after the administration of clomiphene citrate and bromocriptine.

Design: Case report.

Setting: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Korea.

Patient(s): A 34-year-old woman presented with secondary infertility and hyperprolactinemia.

Intervention(s): Bromocriptine, 2.5 mg/day, was administered immediately, and clomiphene citrate, 150 mg/day, was started from menstruation day 5 for 5 days.

Main outcome measure(s): The establishment of pregnancy and obstetric outcome.

Result(s): A nonidentical twin pregnancy occurred but ended in preterm delivery at 24 weeks. One baby has survived for over 3 months.

Conclusion(s): Twin gestation can occur in both horns of a bicornuate uterus after clomiphene citrate administration.

Publication types

  • Case Reports
  • Twin Study

MeSH terms

  • Adult
  • Bromocriptine / pharmacology*
  • Bromocriptine / therapeutic use
  • Clomiphene / pharmacology*
  • Clomiphene / therapeutic use
  • Female
  • Humans
  • Pregnancy
  • Pregnancy, Multiple / drug effects*
  • Pregnancy, Multiple / physiology
  • Stillbirth
  • Uterus / abnormalities*
  • Uterus / drug effects*


  • Clomiphene
  • Bromocriptine