High rate of aneuploidy in luteinized granulosa cells obtained from follicular fluid in women who underwent controlled ovarian hyperstimulation

Semih Kaleli; Gulderen Yanikkaya-Demirel; C Tamer Erel; Levent M Senturk; Ata Topçuoğlu; Tulay Irez

doi:10.1016/j.fertnstert.2005.02.040

High rate of aneuploidy in luteinized granulosa cells obtained from follicular fluid in women who underwent controlled ovarian hyperstimulation

Fertil Steril. 2005 Sep;84(3):802-4. doi: 10.1016/j.fertnstert.2005.02.040.

Authors

Semih Kaleli¹, Gulderen Yanikkaya-Demirel, C Tamer Erel, Levent M Senturk, Ata Topçuoğlu, Tulay Irez

Affiliation

¹ Department of Obstetrics and Gynecology, Istanbul University, Cerrahpaşa School of Medicine, Istanbul, Turkey. semihkaleli@yahoo.com

PMID: 16169431
DOI: 10.1016/j.fertnstert.2005.02.040

Abstract

We performed a prospective study to detect the cell cycle changes in luteinized granulosa cells in patients undergoing controlled ovarian stimulation with GnRH analog and gonadotropin therapy. Aneuploid DNA content was observed in 37 of 70 women (52.9%), and multiple logistic regression analysis revealed that only the dose of gonadotropins used significantly predicted the ploidy status of granulosa cells, which indicates that ovarian hyperstimulation in IVF treatment might be detrimental for the DNA content of granulosa cells.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aneuploidy*
Female
Follicular Fluid / cytology
Follicular Fluid / physiology*
Granulosa Cells / cytology
Granulosa Cells / physiology*
Humans
Luteinization / physiology*
Ovarian Hyperstimulation Syndrome / chemically induced
Ovarian Hyperstimulation Syndrome / physiopathology*
Ovulation Induction / adverse effects*
Ovulation Induction / statistics & numerical data
Prospective Studies