Signal transduction: how rad53 kinase is activated

Curr Biol. 2005 Sep 20;15(18):R769-71. doi: 10.1016/j.cub.2005.08.057.


Recent studies have elucidated the activation mechanism of the Rad53 checkpoint kinase and the role of Rad9-like adaptor proteins in mediating signal transduction from PIKK sensor kinases that detect DNA damage to the effector kinases that play a part in mending that damage.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Checkpoint Kinase 2
  • DNA Damage*
  • Enzyme Activation / physiology
  • Intracellular Signaling Peptides and Proteins
  • Models, Biological*
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction / physiology*
  • Yeasts


  • Adaptor Proteins, Signal Transducing
  • Intracellular Signaling Peptides and Proteins
  • Saccharomyces cerevisiae Proteins
  • Checkpoint Kinase 2
  • MEC1 protein, S cerevisiae
  • Protein-Serine-Threonine Kinases