Peroxisome biogenesis: end of the debate

Curr Biol. 2005 Sep 20;15(18):R774-6. doi: 10.1016/j.cub.2005.08.056.


The long-standing and thorny issue of the origin of peroxisomes has at last been solved. New evidence demonstrates conclusively that the peroxisomal membrane originates from the endoplasmic reticulum. This process requires the two peroxins Pex3p and Pex19p leading to intermediate structures that then mature into functionally competent organelles.

Publication types

  • Comment
  • Review

MeSH terms

  • Endoplasmic Reticulum / metabolism*
  • Intracellular Membranes / metabolism*
  • Membrane Proteins / metabolism*
  • Models, Biological*
  • Peroxisomes / metabolism*
  • Peroxisomes / physiology


  • Membrane Proteins