Comparison of preoperative gastric contents and serum gastrin concentrations in pregnant and nonpregnant women

J Clin Anesth. 2005 Sep;17(6):451-5. doi: 10.1016/j.jclinane.2004.10.010.

Abstract

Study objective: The aim of this study was to compare the volume and the pH level of preoperative gastric contents and serum gastrin concentrations between pregnant and nonpregnant women.

Design: This prospective controlled study was conducted in a single blind manner.

Patients: One hundred pregnant women scheduled for elective cesarean delivery (pregnant group) and 100 nonpregnant women who underwent gynecologic surgery (nonpregnant group) were enrolled.

Interventions: Gastric content was aspirated gently with 14-F multiorificed nasogastric tube before the induction of anesthesia.

Measurements: The volume and the pH level of the aspirated gastric contents were measured, and serum gastrin concentration was measured by the double antibody gastrin method.

Main results: The gastric volume in the pregnant group was greater than in the nonpregnant group (0.49 +/- 0.4 vs 0.24 +/- 0.2 mL/kg, P < .05). The gastric pH level in the pregnant group was lower than in the nonpregnant group (2.4 +/- 1.4 vs 3.0 +/- 1.9, P < .05). The number of patients at risk was 45 (45.5%) in the pregnant group and 16 (16.7%) in the nonpregnant group (P < .05). The serum gastrin levels of the 2 groups were not significantly different (32.1 +/- 12.3 vs 28.2 +/- 8.3 pg/mL). The preoperative anxiety level of the pregnant group was higher than in the nonpregnant group (4.4 +/- 2.1 vs 3.8 +/- 2.2, P < .05).

Conclusions: We confirmed that pregnant women have much greater and more acidic gastric contents than the nonpregnant patients preoperatively, and it is not because of serum gastrin concentration.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Anesthesia, Epidural
  • Anesthesia, Inhalation
  • Anesthesia, Obstetrical
  • Cesarean Section
  • Female
  • Gastric Acidity Determination
  • Gastrins / blood*
  • Gastrointestinal Contents / chemistry*
  • Gynecologic Surgical Procedures
  • Humans
  • Intraoperative Period
  • Pain Measurement
  • Pregnancy / blood*

Substances

  • Gastrins