Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project

Prostate. 2006 Feb 1;66(2):173-9. doi: 10.1002/pros.20332.


Background: Prostate cancer (PC) is a complex disease that displays variable disease outcome, ranging from a relatively indolent disease to forms that result in death from the disease. One measure of disease severity is the Gleason score. Using the Gleason score as a measure of tumor aggressiveness, several independent genome scans have reported evidence of linkage. As of yet, however, no genes have been implicated.

Methods: We report an independent genome scan using the Gleason score as a quantitative trait. We genotyped 405 highly polymorphic microsatellite markers in 175 brother pairs from 103 families.

Results: Our strongest evidence of linkage is to 6q23 at 137 cM (D6S292, P = 0.0009). Other interesting regions (P < 0.005) were on chromosome 1p13-q21 and on chromosome 5p13-q11.

Conclusions: Our results provide further evidence that tumor aggressiveness has a genetic component, and that this genetic component may be influenced by several independent genes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • African Continental Ancestry Group / genetics
  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group / genetics
  • Chromosomes, Human, Pair 1 / genetics
  • Chromosomes, Human, Pair 5 / genetics
  • Chromosomes, Human, Pair 6 / genetics
  • DNA Replication
  • European Continental Ancestry Group / genetics
  • Genetic Linkage*
  • Genetic Predisposition to Disease*
  • Genome, Human*
  • Humans
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • Neoplasm Invasiveness / genetics*
  • Pedigree
  • Prostatic Neoplasms / diagnosis
  • Prostatic Neoplasms / epidemiology
  • Prostatic Neoplasms / ethnology
  • Prostatic Neoplasms / genetics*
  • Quantitative Trait, Heritable
  • Severity of Illness Index