Spinal cord compression by ectopic calcinosis in scleroderma

Clin Exp Rheumatol. 2005 Sep-Oct;23(5):704-6.


Systemic sclerosis (SS) is a chronic, multisystemic disease, characterized by inflammation associated with fibrosis. Calcinosis is one of the manifestations of this disorder, observed in 10 to 20% of cases. It is usually located on the extensor surface of the phalanges, peri-articular tissue and near the bone prominences. There are only a few cases reported of SS with vertebral column involvement and spinal cord compression by calcinosis causing serious neurological complications. We describe a fatal case of SS who showed tetraplegia secondary to ectopic calcinosis in the cervical medulla and present a review of the literature on the subject.

Publication types

  • Case Reports

MeSH terms

  • Calcinosis / diagnostic imaging
  • Calcinosis / etiology
  • Cervical Vertebrae
  • Fatal Outcome
  • Female
  • Humans
  • Laminectomy
  • Middle Aged
  • Scleroderma, Systemic / complications*
  • Spinal Cord Compression / diagnostic imaging
  • Spinal Cord Compression / etiology*
  • Spinal Cord Compression / surgery
  • Thoracic Vertebrae
  • Tomography, X-Ray Computed