Favorable outcomes with tacrolimus in two patients with refractory interstitial lung disease associated with polymyositis/dermatomyositis

Clin Exp Rheumatol. Sep-Oct 2005;23(5):707-10.

Abstract

Two cases of progressive interstitial lung disease associated with polymyositis/dermatomyositis are presented. Both patients were refractory to conventional therapy with high-dose corticosteroids, cyclosporine, and intermittent pulse cyclophosphamide, and thus a therapeutic trial of tacrolimus was instituted. Tacrolimus was markedly effective in achieving subjective, laboratory and radiographic improvement in both patients.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Dermatomyositis / complications*
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Lung Diseases, Interstitial / drug therapy*
  • Lung Diseases, Interstitial / etiology
  • Middle Aged
  • Tacrolimus / therapeutic use*
  • Treatment Failure
  • Treatment Outcome

Substances

  • Immunosuppressive Agents
  • Tacrolimus