A route to annulated indoles via a palladium-catalyzed tandem alkylation/direct arylation reaction

J Am Chem Soc. 2005 Sep 28;127(38):13148-9. doi: 10.1021/ja054472v.


A norbornene-mediated palladium-catalyzed tandem alkylation/C-H functionalization sequence is described, in which an alkyl-aryl bond and a heteroaryl-aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Catalysis
  • Indoles / chemical synthesis*
  • Ligands
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Palladium / chemistry*


  • Indoles
  • Ligands
  • Organometallic Compounds
  • Palladium