The bone marrow vascular niche: home of HSC differentiation and mobilization

Physiology (Bethesda). 2005 Oct:20:349-56. doi: 10.1152/physiol.00025.2005.

Abstract

The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Vessels / physiology
  • Bone Marrow / blood supply*
  • Cell Differentiation*
  • Cell Movement*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Models, Cardiovascular
  • Neovascularization, Physiologic / physiology