Abstract
Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants approximately 10(5) mol(-1) dm(3); the glycosylated arylacetylide complexes exhibit emission at lambda(max) approximately 620 nm in water and are up to approximately 100-times higher in potency than the clinical cisplatin drug in killing cancer cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Chemical Phenomena
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Chemistry, Physical
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Cisplatin / pharmacology
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DNA / chemistry
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DNA / metabolism
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Drug Screening Assays, Antitumor
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Electrophoresis, Polyacrylamide Gel
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Electrophoretic Mobility Shift Assay
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Glycosylation
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Humans
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Ligands
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Luminescence
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Organoplatinum Compounds / chemical synthesis*
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Organoplatinum Compounds / pharmacology
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Photochemistry
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Pyridines / chemical synthesis*
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Restriction Mapping
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Solubility
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Spectrophotometry, Ultraviolet
Substances
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Antineoplastic Agents
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Ligands
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Organoplatinum Compounds
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Pyridines
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DNA
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Cisplatin