Architecture and design of the nuclear pore complex

Cell. 1992 Jun 26;69(7):1133-41. doi: 10.1016/0092-8674(92)90635-p.


A three-dimensional analysis of the nuclear pore complex reveals the underlying, highly symmetric framework of this supramolecular assembly, how it is anchored in the nuclear membrane, and how it is built from many distinct, interconnected subunits. The arrangement of the subunits within the membrane pore creates a large central channel, through which active nucleocytoplasmic transport is known to occur, and eight smaller peripheral channels that are probable routes for passive diffusion of ions and small molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Image Processing, Computer-Assisted
  • Macromolecular Substances
  • Molecular Conformation
  • Nuclear Envelope / ultrastructure*
  • Oocytes
  • Xenopus


  • Macromolecular Substances