Taurine prevents collagen abnormalities in high fructose-fed rats

Indian J Med Res. 2005 Aug;122(2):171-7.


Background & objective: Accumulation of collagen and changes in its physiochemical properties contribute to the development of secondary complications of diabetes. We undertook this study to see the effects of taurine on the content and characteristics of collagen from tail tendon of rats fed with high fructose diet.

Methods: The rats were divided into four groups of six each: control group (CON), taurine-supplemented control group (CON+TAU), taurine supplemented (FRU+TAU) and not supplemented fructose-fed group (FRU). The physico-chemical properties of collagen isolated from the tail tendon were studied.

Results: Fructose administration caused accumulation of collagen in tail tendon. Enhanced glycation and advanced glycation end products (AGE)-linked fluorescence together with alterations in aldehyde content, solubility pattern, susceptibility to denaturing agents and shrinkage temperature were observed in fructose-fed rats. Elevated b component of type I collagen was evidenced from the SDS gel pattern of collagen from the fructose-fed rats. Simultaneous administration of taurine alleviated these changes.

Interpretation & conclusion: Taurine administration to fructose-rats had a positive influence on both quantitative and qualitative properties of collagen. The results of the present study suggested a role for the action of taurine in delaying diabetic complications and the possible use of taurine as an adjuvant therapeutic measure in the management of diabetes and its complications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Animal Nutritional Physiological Phenomena*
  • Animals
  • Antioxidants / pharmacology
  • Collagen / chemistry
  • Collagen / metabolism*
  • Collagen Type I / metabolism
  • Fructose / metabolism
  • Fructose / pharmacology*
  • Glycation End Products, Advanced / metabolism
  • Lipid Peroxidation
  • Male
  • Models, Animal
  • Pepsin A / chemistry
  • Rats
  • Rats, Wistar
  • Salts / pharmacology
  • Sodium Dodecyl Sulfate / chemistry
  • Sodium Dodecyl Sulfate / metabolism
  • Solubility
  • Tail
  • Taurine / chemistry
  • Taurine / metabolism
  • Taurine / pharmacology*
  • Temperature
  • Tendons / metabolism*


  • Amino Acids
  • Antioxidants
  • Collagen Type I
  • Glycation End Products, Advanced
  • Salts
  • Taurine
  • Fructose
  • Sodium Dodecyl Sulfate
  • Collagen
  • Pepsin A