Practice implications with an alcohol-free, 0.07% cetylpyridinium chloride mouthrinse

Am J Dent. 2005 Jul:18 Spec No:29A-34A.


Purpose: Behavioral research was conducted to ascertain the relevance of an alcohol-free, 0.07% cetylpyridinium chloride (CPC) therapeutic mouthrinse to contemporary dental practice over a 6-month usage period.

Methods: A randomized, single-blind study was conducted to assess practice-relevant compliance, acceptability and side effects associated with two mouthrinses. The target population was healthy adult mouthrinse users with a history of routine dental prophylaxis and maintenance care. Subjects were randomly assigned to a therapeutic mouthrinse with 0.07% CPC (Crest Pro-Health Rinse) or a cosmetic rinse control (Scope). Other oral hygiene was not standardized. Subjects completed a questionnaire and were examined by dental hygienists at baseline, and again after 3 and 6 months rinsing. At study completion, a dental prophylaxis was administered.

Results: Compliance was generally favorable, with 273 subjects (89%) completing the 6-month rinsing study. Rinsing time generally stayed the same or increased relative to baseline. Groups differed among the subset who historically used an essential oils rinse (N=137), where those assigned to the alcohol-free therapeutic rinse exhibited significantly (P= 0.02) longer rinsing times compared to subjects using the alcohol-containing cosmetic rinse. Subject evaluations were generally positive with respect to both rinses. Side effects were minimal, with no between-group differences in hygienist-rated calculus or stain accumulation, or prophylaxis time.

Clinical significance: In a 6-month study, a high bioavailable 0.07% CPC therapeutic mouthrinse showed generally high compliance and favorable user acceptability, with similar side effects to those seen with a cosmetic mouthrinse. These findings suggest that the 0.07% CPC mouthrinse may be readily incorporated within the contemporary recall dental practice.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Infective Agents, Local / adverse effects
  • Anti-Infective Agents, Local / therapeutic use*
  • Cetylpyridinium / adverse effects
  • Cetylpyridinium / therapeutic use*
  • Dental Calculus / classification
  • Dental Prophylaxis
  • Drug Combinations
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Mouthwashes / adverse effects
  • Mouthwashes / therapeutic use*
  • Oral Hygiene
  • Patient Compliance*
  • Patient Satisfaction
  • Quaternary Ammonium Compounds / therapeutic use
  • Time Factors
  • Tooth Discoloration / classification


  • Anti-Infective Agents, Local
  • Crest Pro-Health mouthrinse
  • Drug Combinations
  • Mouthwashes
  • Quaternary Ammonium Compounds
  • Scope mouthwash
  • Cetylpyridinium