Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus

Med Mycol. 2005 Aug;43(5):397-401. doi: 10.1080/13693780400005866.


We describe a kinetic microbroth method of measuring the growth rate of Aspergillus fumigatus spectrophotometrically. Using this method, growth rates were determined for nine A. fumigatus isolates for which an LD90 value in immunosuppressed CD-1 mice had previously been obtained. Comparison of the growth rates and LD90 values of these isolates suggests that a correlation exists between the two parameters.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aspergillosis / drug therapy
  • Aspergillosis / microbiology*
  • Aspergillosis / mortality
  • Aspergillus fumigatus / classification
  • Aspergillus fumigatus / growth & development*
  • Aspergillus fumigatus / metabolism
  • Aspergillus fumigatus / pathogenicity*
  • Cell Growth Processes / physiology*
  • Mice
  • Virulence*