Chipping away at the embryonic stem cell network

Cell. 2005 Sep 23;122(6):828-30. doi: 10.1016/j.cell.2005.09.002.

Abstract

Critical transcription factors, notably OCT4, SOX2, and NANOG, are necessary to maintain self-renewal and pluripotency, two properties characteristic of embryonic stem (ES) cells. By analyzing the genome-wide localization of these factors at promoter regions in human ES cells, Boyer et al. (2005) demonstrate frequent promoter co-occupancy at numerous target genes. As they discuss in this issue of Cell, their findings indicate the presence of a complex network of autoregulatory and feedforward loops in human ES cells.

Publication types

  • Comment

MeSH terms

  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Cell Transplantation / physiology
  • DNA-Binding Proteins / metabolism
  • Embryo, Mammalian / cytology*
  • Genes, Regulator / genetics
  • Genes, Regulator / physiology*
  • HMGB Proteins / metabolism
  • Homeodomain Proteins / metabolism
  • Humans
  • Nanog Homeobox Protein
  • Octamer Transcription Factor-3 / metabolism
  • SOXB1 Transcription Factors
  • Signal Transduction / physiology
  • Stem Cells / cytology
  • Stem Cells / physiology*
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • HMGB Proteins
  • Homeodomain Proteins
  • NANOG protein, human
  • Nanog Homeobox Protein
  • Octamer Transcription Factor-3
  • POU5F1 protein, human
  • SOX2 protein, human
  • SOXB1 Transcription Factors
  • Transcription Factors