Dose effects of modafinil in sustaining wakefulness in narcolepsy patients with residual evening sleepiness

J Neuropsychiatry Clin Neurosci. Summer 2005;17(3):405-12. doi: 10.1176/jnp.17.3.405.


Excessive sleepiness associated with narcolepsy lasts throughout the waking day. The authors conducted two randomized, double-blind studies to compare the efficacy of modafinil once-daily versus split doses in maintaining wakefulness throughout the day. Fifty-six patients received modafinil. The split-dose regimens were significantly more effective than the 200-mg once-daily regimen for sustaining wakefulness in the late afternoon/evening. All modafinil dosing regimens were well tolerated. In patients who experience excessive sleepiness in the late afternoon/evening, despite satisfactory treatment earlier in the day, a split dose of modafinil may promote wakefulness throughout the waking day.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Benzhydryl Compounds / therapeutic use*
  • Demography
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Middle Aged
  • Modafinil
  • Narcolepsy / drug therapy*
  • Narcolepsy / etiology
  • Neoplasm, Residual / complications
  • Neoplasm, Residual / drug therapy*
  • Neuroprotective Agents / therapeutic use*
  • Reaction Time
  • Wakefulness / drug effects*


  • Benzhydryl Compounds
  • Neuroprotective Agents
  • Modafinil