Loss of insight and functional neuroimaging in frontotemporal dementia

J Neuropsychiatry Clin Neurosci. 2005 Summer;17(3):413-6. doi: 10.1176/jnp.17.3.413.


Loss of insight is a diagnostic criterion for frontotemporal dementia. It is associated with hypoperfusion/hypometabolism in the right hemisphere, particularly the frontal lobe. Loss of insight is often an anosodiaphoria (i.e., lack of concern) rather than an anosognosia (i.e., decreased awareness).

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Analysis of Variance
  • Dementia / pathology*
  • Dementia / physiopathology*
  • Female
  • Frontal Lobe / pathology
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Mental Status Schedule
  • Middle Aged
  • Neuropsychological Tests
  • Social Behavior Disorders / pathology*
  • Social Behavior Disorders / physiopathology*
  • Temporal Lobe / pathology
  • Tomography, Emission-Computed
  • Tomography, Emission-Computed, Single-Photon