Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?

Eur J Immunol. 2005 Oct;35(10):2789-92. doi: 10.1002/eji.200535446.

Abstract

Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. Küppers has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID-expressing subset in the MZ region. The consequences on the possible origin of these cells are discussed.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • B-Lymphocyte Subsets / cytology*
  • B-Lymphocyte Subsets / immunology*
  • Cell Lineage / immunology*
  • Cytidine Deaminase
  • Cytosine Deaminase / immunology
  • Cytosine Deaminase / metabolism
  • Humans
  • Immunoglobulins / genetics*
  • Mutation
  • Spleen / cytology*
  • Spleen / immunology
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / immunology

Substances

  • Immunoglobulins
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • AICDA (activation-induced cytidine deaminase)
  • Cytosine Deaminase
  • Cytidine Deaminase