Primary pulmonary lymphoma

Ann Thorac Surg. 2005 Oct;80(4):1248-53. doi: 10.1016/j.athoracsur.2005.04.014.


Background: Primary pulmonary lymphoma is a rare disease. The clinical characteristics, methods of treatment, and outcomes are not well elucidated.

Methods: A retrospective review of primary pulmonary lymphoma cases at a single institution from 1990 to 2002 was performed.

Results: Eighteen patients were included, with a mean follow-up of 2.9 years. Fourteen patients had mucosa-associated lymphoid tissue (MALT) lymphoma, 2 had large cell transformation of sheet cells in MALT lymphoma, and 1 each had Hodgkin's disease and follicular lymphoma. Computed tomography-guided biopsy was diagnostic in only two of eight attempts. Eleven patients had disease confined to the pulmonary parenchyma, and 7 had parenchymal disease as well as mediastinal lymphadenopathy. Treatment methods included observation only (n = 1), surgery only (n = 6), surgery plus chemotherapy (n = 8), surgery plus radiotherapy (n = 1), and surgery plus chemotherapy plus radiotherapy (n = 2). Kaplan-Meier estimate of median time to disease recurrence or death was 6 years. Only 1 patient died of disease-related causes. Patients who had bilateral disease were more likely to have recurrent disease or death (p = 0.03).

Conclusions: A wide range of treatments were used for patients with generally MALT lymphoma, resulting in good outcomes, and recurrent disease was well controlled.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Chemotherapy, Adjuvant
  • Female
  • Follow-Up Studies
  • Hodgkin Disease / diagnostic imaging
  • Hodgkin Disease / pathology
  • Hodgkin Disease / surgery
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / therapy*
  • Lymphoma / diagnosis*
  • Lymphoma / therapy*
  • Lymphoma, B-Cell, Marginal Zone / diagnostic imaging
  • Lymphoma, B-Cell, Marginal Zone / pathology
  • Lymphoma, B-Cell, Marginal Zone / surgery
  • Lymphoma, Follicular / diagnostic imaging
  • Lymphoma, Follicular / pathology
  • Lymphoma, Follicular / surgery
  • Male
  • Middle Aged
  • Neoplasm Staging / methods
  • Prognosis
  • Radiography
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Survival Analysis
  • Treatment Outcome