Disposition of quinine in plasma, red blood cells and saliva after oral and intravenous administration to healthy adult Africans

Eur J Clin Pharmacol. 1992;42(2):171-4. doi: 10.1007/BF00278479.


The pharmacokinetics of quinine has been studied in ten healthy adult Africans after intravenous infusion and oral ingestion of a 500 mg dose. Blood and saliva samples were collected over 48 h and quinine in plasma, red cells and saliva was determined by HPLC. Quinine was rapidly and almost completely absorbed after an oral dose, with absorption half-life of 0.53 h, a tmax of 1-3 h and a bioavailability of 88%. Analysis of the i.v. data gave an apparent volume of distribution of 3.6 l.kg-1 and a plasma clearance of 0.19 l.kg-1.h-1. The concentration-time curves for plasma, red cells and saliva had declining phases were approximately parallel, giving a similar half-life that in all three media. The half-lives after the i.v. infusion also did not different from those after oral administration. The dose was well tolerated by both methods of administration.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Chromatography, High Pressure Liquid
  • Erythrocytes / metabolism*
  • Half-Life
  • Humans
  • Injections, Intravenous
  • Male
  • Nigeria
  • Quinine / administration & dosage
  • Quinine / blood
  • Quinine / pharmacokinetics*
  • Saliva / metabolism*


  • Quinine