Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: a therapeutic approach

Eur J Pharmacol. 1992 Jan 28;211(1):121-3. doi: 10.1016/0014-2999(92)90273-7.

Abstract

In this study the effect of purified rat anti-mouse IL-5 monoclonal antibody on aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid of guinea pigs was studied. The i.p. injection of anti-IL-5 antibody 4 h after aeroallergen challenge inhibited eosinophil infiltration in a dose-dependent fashion. The resulting ED50 was 10 (3.4-32.8) micrograms/kg. The clinical therapeutic usefulness of anti-IL-5 or anti-IL-5-producing cells in asthma/allergy treatment remains to be an intriguing possibility.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Asthma / immunology
  • Asthma / therapy*
  • Eosinophilia / immunology
  • Eosinophilia / therapy*
  • Guinea Pigs
  • Interleukin-5 / immunology*
  • Male

Substances

  • Antibodies, Monoclonal
  • Interleukin-5