Cell polarity: ROPing the ends together

Curr Opin Plant Biol. 2005 Dec;8(6):613-8. doi: 10.1016/j.pbi.2005.09.003. Epub 2005 Sep 22.

Abstract

Cell polarity plays an important role in plant development, but the mechanisms that first establish polarity cues remain obscure. By contrast, a flurry of information has recently emerged on the elaboration of cell shape from such unknown initial cell-polarity cues. Recent studies suggest that Rho-related GTPases in plants (ROPs), and their effector targets among the ROP-interactive CRIB motif-containing proteins (RICs), mediate two antagonistic pathways that have opposing action on cell polarization. ROP proteins appear to interact directly with upstream regulators of the ARP2/3 complex, which are conserved modulators of the actin cytoskeleton. ROP function is dependent on the class 1 ADP-ribosylation factors (ARFs), which are core components of the vesicle transport machinery that are also involved in the polar localization of PIN-FORMED (PIN) family auxin efflux facilitators.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADP-Ribosylation Factors / metabolism
  • Actin-Related Protein 2-3 Complex / genetics
  • Actin-Related Protein 2-3 Complex / metabolism
  • Animals
  • Cell Polarity / physiology*
  • Membrane Transport Proteins / metabolism
  • Protein Transport
  • rho GTP-Binding Proteins / metabolism*

Substances

  • Actin-Related Protein 2-3 Complex
  • Membrane Transport Proteins
  • ADP-Ribosylation Factors
  • rho GTP-Binding Proteins