Mild to moderate cystic fibrosis is not associated with increased fracture risk in children and adolescents

J Pediatr. 2005 Sep;147(3):327-31. doi: 10.1016/j.jpeds.2005.04.015.


Objectives: To determine whether children and adolescents with cystic fibrosis (CF), pancreatic insufficiency (PI), and mild-to-moderate lung disease have an increased risk of fracture compared with concurrent healthy control subjects.

Study design: A lifetime fracture history questionnaire was administered to 186 subjects (ages 6 to 25 years) with CF, PI and mild-to-moderate lung disease and 427 healthy white control subjects (ages 4 to 25 years).

Results: A fracture was reported by 24% of subjects with CF and 23% of healthy control subjects. Average age of first fracture was similar between the groups (8.3 years for subjects and 8.8 years for controls). The radius/ulna was the most common fracture site in both groups. Risk of fracture, adjusted for sex and age, was not greater in the CF group compared with the control group (hazard ratio: 0.96, 95% CI: 0.68, 1.30, P = .82).

Conclusion: Children and adolescents with CF, PI, and mild-to-moderate lung disease were not at an increased risk of fracture.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Body Weights and Measures
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cystic Fibrosis / complications*
  • Exocrine Pancreatic Insufficiency / complications
  • Female
  • Forced Expiratory Volume
  • Fractures, Bone / epidemiology*
  • Fractures, Bone / etiology*
  • Humans
  • Male
  • Prevalence
  • Risk Assessment
  • Severity of Illness Index