Inhibitors of the serotonin transporter protein (SERT): the design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5307-10. doi: 10.1016/j.bmcl.2005.08.030. Epub 2005 Sep 23.

Abstract

There is a growing demand for compounds with specificity for the serotonin transporter protein (SERT) that can be conjugated to cadmium selenide/zinc sulfide core shell nanocrystals. This letter describes the design and synthesis of two different biotinylated SERT antagonists that can be attached to streptavidin-coated cadmium selenide/zinc sulfide core shell nanocrystals.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biotinylation
  • Humans
  • Imidazoles / chemical synthesis
  • Imidazoles / chemistry*
  • Imidazoles / pharmacology
  • Indoles / chemical synthesis
  • Indoles / chemistry*
  • Indoles / pharmacology
  • Ligands
  • Molecular Structure
  • Quantum Dots*
  • Serotonin Plasma Membrane Transport Proteins / metabolism*
  • Serotonin Uptake Inhibitors / chemical synthesis
  • Serotonin Uptake Inhibitors / chemistry*
  • Serotonin Uptake Inhibitors / pharmacology

Substances

  • Imidazoles
  • Indoles
  • Ligands
  • N-(2-(4-(1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl-5-(2-oxohexahydro-1H-thieno(3,4-d)imidazol-4-yl)pentanamide)
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin Uptake Inhibitors