Abstract
There is a growing demand for compounds with specificity for the serotonin transporter protein (SERT) that can be conjugated to cadmium selenide/zinc sulfide core shell nanocrystals. This letter describes the design and synthesis of two different biotinylated SERT antagonists that can be attached to streptavidin-coated cadmium selenide/zinc sulfide core shell nanocrystals.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Biotinylation
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Humans
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Imidazoles / chemical synthesis
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Imidazoles / chemistry*
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Imidazoles / pharmacology
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Indoles / chemical synthesis
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Indoles / chemistry*
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Indoles / pharmacology
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Ligands
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Molecular Structure
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Quantum Dots*
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Selective Serotonin Reuptake Inhibitors / chemical synthesis
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Selective Serotonin Reuptake Inhibitors / chemistry*
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Selective Serotonin Reuptake Inhibitors / pharmacology
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Serotonin Plasma Membrane Transport Proteins / metabolism*
Substances
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Imidazoles
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Indoles
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Ligands
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N-(2-(4-(1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl-5-(2-oxohexahydro-1H-thieno(3,4-d)imidazol-4-yl)pentanamide)
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Serotonin Uptake Inhibitors