Duplication of the hypophysis associated with precocious puberty: presentation of two cases and review of pituitary embryogenesis

Arq Bras Endocrinol Metabol. 2005 Apr;49(2):323-7. doi: 10.1590/s0004-27302005000200023. Epub 2005 Sep 12.


Pituitary duplication is a rare malformation commonly associated with other major neural/craniofacial anomalies, easily shown by magnetic resonance imaging. The authors describe two girls with duplication of the pituitary gland and thickening of the hypothalamus, facial dysmorphism and precocious pubertal development. The pathogenesis of pituitary duplication and its relationship with precocious pubertal development are discussed.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Pituitary Gland / abnormalities*
  • Pituitary Gland / embryology
  • Puberty, Precocious / etiology*