Prostate cancer risk among men with diabetes mellitus (Spain)

Cancer Causes Control. 2005 Nov;16(9):1055-8. doi: 10.1007/s10552-005-4705-5.


Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK.

Methods: Population based case-control study nested in a cohort.

Results: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas.

Conclusion: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Case-Control Studies
  • Databases as Topic
  • Diabetes Mellitus / drug therapy*
  • Family Practice
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use*
  • Incidence
  • Male
  • Prostatic Neoplasms / epidemiology*
  • Prostatic Neoplasms / prevention & control
  • Risk
  • Risk Assessment
  • Risk Factors
  • United Kingdom / epidemiology


  • Hypoglycemic Agents