Myelofibrosis-associated massive splenomegaly: a cause of increased intra-abdominal pressure, pulmonary hypertension, and positional dyspnea

Am J Hematol. 2005 Oct;80(2):128-32. doi: 10.1002/ajh.20388.


We describe a patient with myelofibrosis, giant splenomegaly, and pulmonary hypertension related to increased intra-abdominal pressure. Focusing on alterations in hemodynamic studies, we conclude that in patients with myelofibrosis, dyspnea, and hypoxemia, the measurement of intra-abdominal pressure should be included in the initial evaluation. It is an inexpensive, non-invasive diagnostic tool that can provide crucial information about the cause of dyspnea and disclose the pathogenetic link between massive splenomegaly and pulmonary compromise in myelofibrosis.

Publication types

  • Case Reports

MeSH terms

  • Abdomen
  • Dyspnea / etiology
  • Female
  • Heart Function Tests
  • Humans
  • Hypertension, Pulmonary / etiology*
  • Hypoxia
  • Middle Aged
  • Pressure
  • Primary Myelofibrosis / complications*
  • Primary Myelofibrosis / drug therapy
  • Splenomegaly / complications*