Non-specific effects of vaccination on child survival? A prospective study in Senegal

Trop Med Int Health. 2005 Oct;10(10):956-60. doi: 10.1111/j.1365-3156.2005.01479.x.


Objectives: Several studies have shown an association between vaccination and child mortality in developing countries. The present paper examines this issue using data from a Senegalese rural area which has been monitored from 1983 to the present.

Methods: We analysed two birth cohorts, comprising 7796 and 3573 persons who had received either BCG and DTP (diphtheria-tetanus-pertussis) simultaneously or neither of these vaccines, and who had been followed from birth to 2 years of age. The association between vaccinations and mortality was assessed by Cox proportional hazards model.

Results: Mortality ratios for recipients of the BCG/DTP combination were 0.59 (95% CI: 0.46-0.74) for the first cohort and 0.70 (0.50-0.97) for the second cohort. Mortality ratios for measles vaccine recipients were 0.98 (0.75-1.27) for the first cohort and 0.87 (0.57-1.30) for the second cohort.

Conclusions: The BCG/DTP combination was associated with a reduction in mortality whereas measles vaccination was not associated with mortality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • BCG Vaccine / administration & dosage
  • Cohort Studies
  • Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
  • Female
  • Humans
  • Infant
  • Infant Mortality*
  • Male
  • Mass Vaccination / methods*
  • Measles Vaccine / administration & dosage
  • Prospective Studies
  • Rural Health / statistics & numerical data
  • Senegal / epidemiology


  • BCG Vaccine
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Measles Vaccine