Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2005 Oct;13(10):790-6.
doi: 10.1007/s00520-005-0790-y. Epub 2005 Mar 15.

A Randomised, Double-Blinded, Placebo-Controlled, Pilot Study of Parenteral Glutamine for Allogeneic Stem Cell Transplant Patients

Affiliations
Randomized Controlled Trial

A Randomised, Double-Blinded, Placebo-Controlled, Pilot Study of Parenteral Glutamine for Allogeneic Stem Cell Transplant Patients

N M A Blijlevens et al. Support Care Cancer. .

Abstract

We conducted a prospective, randomised, double-blinded, placebo-controlled pilot study of parenteral nutrition (PN) supplemented with 0.57 g/kg glutamine-dipeptide in a homogeneous group of 32 allogeneic stem cell transplant (SCT) recipients to determine its effect on mucosal barrier injury (MBI). All patients had been prepared with idarubicin, cyclophosphamide and total body irradiation. PN (by continuous infusion) started on SCT day -6 for a median of 19 days. MBI measured by sugar permeability tests, daily mucositis score, daily gut score, and citrulline concentrations was not reduced by glutamine-dipeptide. However, the daily gut score was significantly lower for the glutamine group on SCT +7 (p = 0.001) whilst citrulline was lower (p = 0.03) for the placebo group on SCT day +21. Albumin was significantly lower in the placebo group on SCT day +21 (32+/-4 versus 37+/-3, p = 0.001) whilst CRP was higher (74+/-48 versus 34+/-38, p = 0.003). Other transplant-related complications (infections, acute graft-versus-host disease) were less common although this did not reach statistical significance nor translate into a reduced length of hospital stay or lower mortality. These results indicate that it would be worthwhile conducting a larger trial to see whether or not giving glutamine-dipeptide reduces the 100-day allogeneic transplant-related complications.

Similar articles

See all similar articles

Cited by 9 articles

See all "Cited by" articles

References

    1. Bone Marrow Transplant. 2000 Jun;25(12):1269-78 - PubMed
    1. Bone Marrow Transplant. 1998 Aug;22(4):339-44 - PubMed
    1. Ann Intern Med. 1992 May 15;116(10):821-8 - PubMed
    1. Cancer. 2005 Jan 1;103(1):191-9 - PubMed
    1. Cancer. 2003 Oct 1;98(7):1531-9 - PubMed

Publication types

LinkOut - more resources

Feedback