Indian hedgehog: its roles and regulation in endochondral bone development

J Cell Biochem. 2005 Dec 15;96(6):1163-73. doi: 10.1002/jcb.20635.


Normal endochondral bone development requires the coordination of chondrocyte proliferation and differentiation. Indian hedgehog (Ihh) is a morphogen produced by chondrocytes in the early stage of terminal differentiation and plays several key roles in this process. Ihh regulates growth of adjacent proliferative chondrocytes and can also regulate the rate of differentiation of chondrocytes indirectly through its stimulation of parathyroid hormone-related protein (PTHrP). In this review, we focus on recent studies that have identified new functions of Ihh and how Ihh itself is being regulated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inducing Agents / metabolism
  • Animals
  • Bone Development / drug effects
  • Bone Development / physiology*
  • Bone Morphogenetic Proteins / metabolism
  • Cell Differentiation
  • Cell Proliferation
  • Chondrocytes / metabolism*
  • Hedgehog Proteins
  • Humans
  • Models, Biological
  • Morphogenesis / physiology
  • Parathyroid Hormone-Related Protein / metabolism
  • Signal Transduction / physiology
  • Trans-Activators / pharmacology
  • Trans-Activators / physiology*
  • Transforming Growth Factor beta / metabolism


  • Angiogenesis Inducing Agents
  • Bone Morphogenetic Proteins
  • Hedgehog Proteins
  • Parathyroid Hormone-Related Protein
  • Trans-Activators
  • Transforming Growth Factor beta