Effect of spirulina and Liv-52 on cadmium induced toxicity in albino rats

Indian J Exp Biol. 2005 Sep;43(9):773-81.

Abstract

Oral administration of cadmium (6mg/kg body weight/day) as cadmium chloride (CdCl2) for 30 days resulted in a significant increase in thiobarbituric acid reactive substances (TBARS) level and a decrease in the levels of copper, zinc, iron, selenium, glutathione, superoxide dismutase, catalase, glutathione peroxidase when compared to normal control. Administration of either Liv-52 alone or in combination with spirulina produced a well pronounced protective effect in respect to these parameters in cadmium intoxicated rats. The protective effect of spirulina and Liv-52 in respect to biochemical changes were also confirmed by histopathological study in the liver and kidney sections.

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Appetite Depressants / pharmacology
  • Bacterial Proteins / pharmacology*
  • Cadmium / toxicity*
  • Cadmium Chloride / toxicity
  • Catalase / blood
  • Copper / blood
  • Drug Combinations
  • Glutathione / blood
  • Glutathione Peroxidase / blood
  • Iron / blood
  • Kidney / metabolism
  • Kidney / pathology
  • Liver / metabolism
  • Liver / pathology
  • Male
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Selenium / blood
  • Spirulina
  • Superoxide Dismutase / blood
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Zinc / blood

Substances

  • Antioxidants
  • Appetite Depressants
  • Bacterial Proteins
  • Drug Combinations
  • Plant Extracts
  • Thiobarbituric Acid Reactive Substances
  • Cadmium
  • Liv 52
  • Copper
  • Iron
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione
  • Selenium
  • Zinc
  • Cadmium Chloride